Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003
Identifieur interne : 006403 ( Main/Exploration ); précédent : 006402; suivant : 006404Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003
Auteurs : N. S. Zhong [République populaire de Chine] ; B. J. Zheng [Hong Kong] ; Y. M. Li [République populaire de Chine] ; L. L. M. Poon [Hong Kong] ; Z. H. Xie [République populaire de Chine] ; K. H. Chan [Hong Kong] ; P. H. H. Li [Hong Kong] ; S. Y. Tan [République populaire de Chine] ; Q. Chang [République populaire de Chine] ; J. P. Xie [République populaire de Chine] ; X. Q. Liu [République populaire de Chine] ; J. Xu [République populaire de Chine] ; D. X. Li [République populaire de Chine] ; K. Y. Yuen [Hong Kong] ; J. S. M. Peiris [Hong Kong] ; Y. Guan [Hong Kong]Source :
- Lancet : (British edition) [ 0140-6736 ] ; 2003.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Virus du SRAS.
- immunologie : Virus du SRAS.
- isolement et purification : Virus du SRAS.
- microbiologie : Syndrome respiratoire aigu sévère.
- épidémiologie : Chine, Syndrome respiratoire aigu sévère.
- Pascal (Inist)
- Wicri :
- geographic : République populaire de Chine.
- topic : Homme.
English descriptors
- KwdEn :
- Acute, China, China (epidemiology), Disease Outbreaks (statistics & numerical data), Epidemic, Epidemiology, Etiology, Human, Humans, Respiratory distress, SARS Virus (genetics), SARS Virus (immunology), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (microbiology), Viral disease.
- MESH :
- geographic , epidemiology : China.
- epidemiology : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- immunology : SARS Virus.
- isolation & purification : SARS Virus.
- microbiology : Severe Acute Respiratory Syndrome.
- statistics & numerical data : Disease Outbreaks.
- Humans.
Abstract
Background An epidemic of severe acute respiratory syndrome (SARS) has been associated with an outbreak of atypical pneumonia originating in Guangdong Province, People's Republic of China. We aimed to identify the causative agent in the Guangdong outbreak and describe the emergence and spread of the disease within the province. Methods We analysed epidemiological information and collected serum and nasopharyngeal aspirates from patients with SARS in Guangdong in mid-February, 2003. We did virus isolation, serological tests, and molecular assays to identify the causative agent. Findings SARS had been circulating in other cities of Guangdong Province for about 2 months before causing a major outbreak in Guangzhou, the province's capital. A novel coronavirus, SARS coronavirus (CoV), was isolated from specimens from three patients with SARS. Viral antigens were also directly detected in nasopharyngeal aspirates from these patients. 48 of 55 (87%) patients had antibodies to SARS CoV in their convalescent sera. Genetic analysis showed that the SARS CoV isolates from Guangzhou shared the same origin with those in other countries, and had a phylogenetic pathway that matched the spread of SARS to the other parts of the world. Interpretation SARS CoV is the infectious agent responsible for the epidemic outbreak of SARS in Guangdong. The virus isolated from patients in Guangdong is the prototype of the SARS CoV in other regions and countries.
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Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003</title><author><name sortKey="Zhong, N S" sort="Zhong, N S" uniqKey="Zhong N" first="N. S." last="Zhong">N. S. Zhong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, B J" sort="Zheng, B J" uniqKey="Zheng B" first="B. J." last="Zheng">B. J. Zheng</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Li, Y M" sort="Li, Y M" uniqKey="Li Y" first="Y. M." last="Li">Y. M. Li</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L. L. M." last="Poon">L. L. M. Poon</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Xie, Z H" sort="Xie, Z H" uniqKey="Xie Z" first="Z. H." last="Xie">Z. H. Xie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K. H." last="Chan">K. H. Chan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Li, P H H" sort="Li, P H H" uniqKey="Li P" first="P. H. H." last="Li">P. H. H. Li</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Tan, S Y" sort="Tan, S Y" uniqKey="Tan S" first="S. Y." last="Tan">S. Y. Tan</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Guangzhou Chest Hospital</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou Chest Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Q" sort="Chang, Q" uniqKey="Chang Q" first="Q." last="Chang">Q. Chang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Xie, J P" sort="Xie, J P" uniqKey="Xie J" first="J. P." last="Xie">J. P. Xie</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Guangzhou Children's Hospital</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou Children's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Liu, X Q" sort="Liu, X Q" uniqKey="Liu X" first="X. Q." last="Liu">X. Q. Liu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Xu, J" sort="Xu, J" uniqKey="Xu J" first="J." last="Xu">J. Xu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Li, D X" sort="Li, D X" uniqKey="Li D" first="D. X." last="Li">D. X. Li</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Guangzhou Chest Hospital</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou Chest Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. 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S." last="Zhong">N. S. Zhong</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Zheng, B J" sort="Zheng, B J" uniqKey="Zheng B" first="B. J." last="Zheng">B. J. Zheng</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Li, Y M" sort="Li, Y M" uniqKey="Li Y" first="Y. M." last="Li">Y. M. Li</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L. L. M." last="Poon">L. L. M. Poon</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Xie, Z H" sort="Xie, Z H" uniqKey="Xie Z" first="Z. H." last="Xie">Z. H. Xie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K. H." last="Chan">K. H. Chan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Li, P H H" sort="Li, P H H" uniqKey="Li P" first="P. H. H." last="Li">P. H. H. Li</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Tan, S Y" sort="Tan, S Y" uniqKey="Tan S" first="S. Y." last="Tan">S. Y. Tan</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Guangzhou Chest Hospital</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou Chest Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Q" sort="Chang, Q" uniqKey="Chang Q" first="Q." last="Chang">Q. Chang</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Xie, J P" sort="Xie, J P" uniqKey="Xie J" first="J. P." last="Xie">J. P. Xie</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Guangzhou Children's Hospital</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>10 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou Children's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Liu, X Q" sort="Liu, X Q" uniqKey="Liu X" first="X. Q." last="Liu">X. Q. Liu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Xu, J" sort="Xu, J" uniqKey="Xu J" first="J." last="Xu">J. Xu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou, Guangdong Province</wicri:noRegion></affiliation></author><author><name sortKey="Li, D X" sort="Li, D X" uniqKey="Li D" first="D. X." last="Li">D. X. Li</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Guangzhou Chest Hospital</s1><s2>Guangzhou, Guangdong Province</s2><s3>CHN</s3><sZ>8 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>Guangzhou Chest Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Microbiology, University of Hong Kong, University Pathology Building, Queen Mary Hospital</s1><s2>Pokfulam</s2><s3>HKG</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Hong Kong</country><wicri:noRegion>Pokfulam</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Lancet : (British edition)</title><title level="j" type="abbreviated">Lancet : (Br. ed.)</title><idno type="ISSN">0140-6736</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Lancet : (British edition)</title><title level="j" type="abbreviated">Lancet : (Br. ed.)</title><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term><term>China</term><term>China (epidemiology)</term><term>Disease Outbreaks (statistics & numerical data)</term><term>Epidemic</term><term>Epidemiology</term><term>Etiology</term><term>Human</term><term>Humans</term><term>Respiratory distress</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (microbiology)</term><term>Viral disease</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Chine (épidémiologie)</term><term>Flambées de maladies ()</term><term>Humains</term><term>Syndrome respiratoire aigu sévère (microbiologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Disease Outbreaks</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Chine</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Détresse respiratoire</term><term>Aigu</term><term>Epidémiologie</term><term>Etiologie</term><term>Chine</term><term>Flambées de maladies</term><term>Homme</term><term>Epidémie</term><term>Humains</term><term>Virose</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background An epidemic of severe acute respiratory syndrome (SARS) has been associated with an outbreak of atypical pneumonia originating in Guangdong Province, People's Republic of China. We aimed to identify the causative agent in the Guangdong outbreak and describe the emergence and spread of the disease within the province. Methods We analysed epidemiological information and collected serum and nasopharyngeal aspirates from patients with SARS in Guangdong in mid-February, 2003. We did virus isolation, serological tests, and molecular assays to identify the causative agent. Findings SARS had been circulating in other cities of Guangdong Province for about 2 months before causing a major outbreak in Guangzhou, the province's capital. A novel coronavirus, SARS coronavirus (CoV), was isolated from specimens from three patients with SARS. Viral antigens were also directly detected in nasopharyngeal aspirates from these patients. 48 of 55 (87%) patients had antibodies to SARS CoV in their convalescent sera. Genetic analysis showed that the SARS CoV isolates from Guangzhou shared the same origin with those in other countries, and had a phylogenetic pathway that matched the spread of SARS to the other parts of the world. Interpretation SARS CoV is the infectious agent responsible for the epidemic outbreak of SARS in Guangdong. The virus isolated from patients in Guangdong is the prototype of the SARS CoV in other regions and countries.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhong, N S" sort="Zhong, N S" uniqKey="Zhong N" first="N. S." last="Zhong">N. S. Zhong</name></noRegion><name sortKey="Chang, Q" sort="Chang, Q" uniqKey="Chang Q" first="Q." last="Chang">Q. Chang</name><name sortKey="Li, D X" sort="Li, D X" uniqKey="Li D" first="D. X." last="Li">D. X. Li</name><name sortKey="Li, Y M" sort="Li, Y M" uniqKey="Li Y" first="Y. M." last="Li">Y. M. Li</name><name sortKey="Liu, X Q" sort="Liu, X Q" uniqKey="Liu X" first="X. Q." last="Liu">X. Q. Liu</name><name sortKey="Tan, S Y" sort="Tan, S Y" uniqKey="Tan S" first="S. Y." last="Tan">S. Y. Tan</name><name sortKey="Xie, J P" sort="Xie, J P" uniqKey="Xie J" first="J. P." last="Xie">J. P. Xie</name><name sortKey="Xie, Z H" sort="Xie, Z H" uniqKey="Xie Z" first="Z. H." last="Xie">Z. H. Xie</name><name sortKey="Xu, J" sort="Xu, J" uniqKey="Xu J" first="J." last="Xu">J. Xu</name></country><country name="Hong Kong"><noRegion><name sortKey="Zheng, B J" sort="Zheng, B J" uniqKey="Zheng B" first="B. J." last="Zheng">B. J. Zheng</name></noRegion><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K. H." last="Chan">K. H. Chan</name><name sortKey="Guan, Y" sort="Guan, Y" uniqKey="Guan Y" first="Y." last="Guan">Y. Guan</name><name sortKey="Li, P H H" sort="Li, P H H" uniqKey="Li P" first="P. H. H." last="Li">P. H. H. Li</name><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J. S. M." last="Peiris">J. S. M. Peiris</name><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L. L. M." last="Poon">L. L. M. Poon</name><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K. Y." last="Yuen">K. Y. Yuen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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